3D-form metrology of arbitrary optical surfaces by absorption in fluids

We present an imaging technique for the 3D-form metrology of optical surfaces. It is based on the optical absorption in fluids situated between the surface and a reference. An improved setup with a bi-chromatic light source is fundamental to obtain reliable topographic maps. It is able to measure any surface finish (rough or polished), form and slope and independently of scale. We present results focused on flat and spherical optical surfaces, arrays of lenses and with different surface finish (rough-polished). We achieve form accuracies from several nanometers to sub-lambda for sag departures from tens to hundred of microns. Therefore, it seems suitable for the quality control in the production of precision aspheric, freeform lenses and other complex shapes on transparent substrates, independently of the surface finish

Virtual restoration and visualization changes through light: A review

This article belongs to the Special Issue Optical Technologies Applied to Cultural Heritage.The virtual modification of the appearance of an object using lighting technologies has become very important in recent years, since the projection of light on an object allows us to alter its appearance in a virtual and reversible way. Considering the limitation of non-contact when analysing a work of art, these optical techniques have been used in fields of restoration of cultural heritage, allowing us to visualize the work as it was conceived by its author, after a process of acquisition and treatment of the image. Furthermore, the technique of altering the appearance of objects through the projection of light has been used in projects with artistic or even educational purposes. This review has treated the main studies of light projection as a technique to alter the appearance of objects, emphasizing the calibration methods used in each study, taking into account the importance of a correct calibration between devices to carry out this technology. In addition, since the described technique consists of projecting light, and one of the applications is related to cultural heritage, those studies that carry out the design and optimization of lighting systems will be described for a correct appreciation of the works of art, without altering its state of conservationThis work has been funded by project number RTI2018-097633-A-I00 of the Ministry of Science and Innovation of Spain, entitled 'Photonic restoration applied to cultural heritage: Application to Dali's painting: Two Figures.

Static and dynamic detection of axial surface defects on metallic wires by conical triple laser reflection

The quality of the surface of metallic wires is relevant for different applications. The reflection of a laser beam on the surface of a metallic cylindrical wire provides an efficient way to inspect the quality of its surface. Our interest is focused in the detection of axially oriented defects, which are the most relevant for the wire drawing process. We present a simple interference-geometrical model to describe the light pattern reflected from a wire with defects. This model adequately accounts for the observed results from an industrial prototype developed for the purpose. It incorporates three-laser beams incident on the wire at equidistant locations in its perimeter, which produce three reflection cones with a CCD. This configuration permits to explore the whole perimeter of the wire. Several results are presented, both in static operation and in production line, in agreement with qualitative and quantitative predictions

Diffraction in wide slits with semi-cylindrical edges

We present an analytical model to obtain the diffraction pattern in far field of a metallic, thick slit based on the Geometrical Theory of Diffraction. The edges of the slit are modelled as semicylinders. We have considered that the thickness of the slit is sufficiently small compared to the width, so that the influence of multiple reflections between the edges may be neglected. The material in which the slit is made, as well as the polarization and angle of the incident beam, are considered. Notorious differences are obtained when compared to the classical diffraction from flat slits

Economic Evaluation of Fluticasone Propionate/ Formoterol (Flutiform ) vs. Fluticasone/Salmeterol and Budesonide/Formoterol in Spain.

Introduction: The aim of this economic evaluation was to estimate the cost-effectiveness of fluticasone propionate/formoterol (FP/FORM; Flutiform ) and compare it to those of fluticasone/ salmeterol (FS) and budesonide/formoterol (BF) when used in the treatment of adult patients with moderate-to-severe asthma. Methods: A Markov model was developed with five asthma health states: successful control, suboptimal control, outpatient-managed exacerbation, inpatient-managed exacerbation, and death. The time horizon was set at 12 months. Transition probabilities and indirect resource utilization were derived from previous international and Spanish publications. Univariate and probabilistic sensitivity analyses (SAs) were applied. Results: FP/FORM was less expensive to acquire than FS or BF (20% lower than FS and 30% lower than BF), while the quality-adjusted life years (QALYs) of the three options compared were very similar. Cost per patient in the FP/FORM cohort was 9326€/year, making it the cheapest option, 1.5% cheaper than FS and 2.6% cheaper than BF. The suboptimal control health state dominated the costs (80% of the total cost) in each of the analyzed options and scenarios. The results of the SAs verified the data obtained from the base case scenario. Conclusions: From a Spanish societal perspective, in 2014, FP/FORM produced a similar gain in QALYs but at a lower cost when compared to FS and BF in a highly meaningful number of replications and scenarios. FP/FORM can therefore be considered a cost-effective option in the treatment of moderate-to-severe asthma in Spain. The cost savings were mainly due to the significantly lower acquisition cost of FP/FORM than the other two options.post-print872 K

The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control

Monkeypox; PCR; Quality controlVerola del mico; PCR; Control de qualitatViruela del mono; PCR; Control de calidadTo evaluate molecular assays for Mpox diagnosis available in various clinical microbiology services in Spain through a quality control (QC) approach. A total of 14 centers from across Spain participated in the study. The Reference Laboratory dispatched eight serum samples and eight nucleic acid extracts to each participating center. Some samples were spiked with Mpox or Vaccinia virus to mimic positive samples for Mpox or other orthopox viruses. Participating centers provided information on the results obtained, as well as the laboratory methods used. Among the 14 participating centers seven different commercial assays were employed, with the most commonly used kit being LightMix Modular Orthopox/Monkeypox (Mpox) Virus (Roche®). Of the 12 centers conducting Mpox determinations, concordance ranged from 62.5% (n = 1) to 100% (n = 11) for eluates and from 75.0% (n = 1) to 100% (n = 10) for serum. Among the 10 centers performing Orthopoxvirus determinations, a 100% concordance was observed for eluates, while for serum, concordance ranged from 87.5% (n = 6) to 100% (n = 4). Repeatedly, 6 different centers reported a false negative in serum samples for Orthopoxvirus diagnosis, particularly in a sample with borderline Ct = 39. Conversely, one center, using the TaqMan™ Mpox Virus Microbe Detection Assay (Thermo Fisher), reported false positives in Mpox diagnosis for samples spiked with vaccinia virus due to cross-reactions. We observed a positive correlation of various diagnostic assays for Mpox used by the participating centers with the reference values. Our results highlight the significance of standardization, validation, and ongoing QC in the microbiological diagnosis of infectious diseases, which might be particularly relevant for emerging viruses.This research was supported by CIBER (Strategic Action for Monkeypox)—Consorcio Centro de Investigación Biomédica en Red—(CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea—NextGenerationEU. A. d. S. is supported by ‘Instituto de Salud Carlos III’ (grant number JR22/00055)

Improvement of driver night vision in foggy environments by structured light projection

Nowadays, fog is still a natural phenomenon that hinders our ability to detect targets, particularly in the field of driving where accidents are increasing. In the literature we find different studies determining the range of visibility, improving the quality of an image, determining the characteristics of fog, etc. In this work we propose the possibility of using a structured lighting system, on which we project the light towards the target, limiting the field lighting. We have developed a scattering light propagation model to simulate and subsequently study the veil luminance, generated by backscattering, to predict the decrease in visibility. This simulation considers the type of fog, the relative orientation of various elements (observer, light source and targets). We have built a fog chamber to validate the experimental params of the described system. The results obtained from both the simulation and the experimental measurements demonstrate that it is possible to obtain a high contrast enhancement for viewing a target when illuminated as described. Clearly, this kind of lighting technology will improve the road safety in foggy night environments. The results of this work can also be extrapolated to any situation in which the visibility of an observer is compromised by the environment, such as heavy rain, smoke from fires, among others

Integrated water vapor over the Arctic: Comparison between radiosondes and sun photometer observations

Producción CientíficaThe amplification of global warming because of the feedbacks associated with the increase in atmospheric moisture and the decrease in sea ice and snow cover in the Arctic is currently the focus of scientists, policy makers and society. The amplification of global warming is the response to increases in precipitation originally caused by climate change. Arctic predominant increases in specific humidity and precipitation have been documented by observations. In comparison, evapotranspiration in the Arctic is poorly known, in part, because the spatial and temporal sparsity of accurate in situ and remote sensing observations. Although more than 20 observations sites in the Arctic are available, where AERONET sun photometer integrated water vapor (IWV) measurements have been conducted, that information have been barely used. Here, we present a comparison of IWV observations from radiosondes and AERONET sun photometers at ten sites located across the Arctic with the goal to document the feasibility of that set of observations to contribute to the ongoing and future research on polar regions. Sun photometer IWV observations are averaged for three-time windows; 30 min, 6 and 24 h. The predominant dry bias of AERONET IWV observations with respect to radiosondes, identified at tropical and midlatitudes, is also present in the Arctic. The statistics of the comparison show robust results at eight of the ten sites, with precision and accuracy magnitudes below 8 and 2% respectively. The possible causes of the less robust results at the other two sites are discussed. In addition, the impact of selecting other temporal coincidence windows in the average sun photometer IWV used in the comparison were tested. Auto-correlation in diurnal sun photometer IWV could produce appreciable bias in the statistics used for the comparison. We suggest using only one pair of values per day, consisting in the daily mean IWV sun photometer and the IWV radiosonde observation value. This feature should be valid also for comparison of IWV from sun photometer and other instruments. Maximum 10% error level of IWV from sun photometer observations, when compared with radiosondes, have been found for the Arctic. It is in the same order of magnitude than at tropical and middle latitudes locations. It has been demonstrated the feasibility of AERONET IWV observations in the Arctic for research on this variable. AERONET standard instruments and its centralized-standard processing algorithm allow its IWV observations to be considered a relative standard dataset for the re-calibration of other instrumental IWV observations assuming radiosondes as the absolute standard dataset.Ministerio de Ciencia, Innovación y Universidades (grant RTI2018-097864-B-I00)Junta de Castilla y León (grant VA227P20)Junta de Extremadura - Fondo Europeo de Desarrollo Regional (grant GR21080 and project IB18092